With 6 cGMP/ FDA inspected plants in Europe and the United States for commercial production supported by two pre-GMP (ISO 9001) sites in France, our customers have access to a powerful industrial network of facilities with a high level of quality, safety and environmental compliance.

Seqens invests on an ongoing basis in its production sites to provide the pharmaceutical industry with state-of-the-art equipment combined with cutting-edge technology in organic chemistry associated with proprietary gene shuffling technology for unique biocatalytic routes.

We conduct GMP manufacturing of APIs or intermediates from kilo to multi-ton quantities. Our range of scale and seamless collaboration within our manufacturing sites allow Seqens to accommodate most projects regardless of size and complexity.

Our services include:

  • Process and analytical validation
  • Kilo-scale, pilot scale and commercial multi-ton cGMP manufacturing
  • Production in two locations for supply chain security
  • Quality control and quality assurance
  • Back integration of early intermediates for  supply chain security, cost or quality control
  • Special technologies like cryogenic, hydrogenation, biocatalysis
  • HPAPI containment down to 100 ng/m3 OEL ( kilo scale to 200 kg batch size )
  • Process optimization and second generation process for cost control
  • Regulatory support and filings

Our locations

Address Route de Lassay
61410 Couterne
Business Line Lubbricant Additives, Fine Chemicals
Phone +33 2 33 37 50 20
Market Specialty Ingredients
Mail info.AS@seqens.com
More information

Surface: 120, 000 m²

Capabilities: 190 m³ of ISO 9001 reactors and kilo-lab

Flagship technologies: Most standard organic synthesis reactions (large volumes)

Certifications: ISO 9001

Address Raiffeisenstraße 4
77933 Lahr
Business Line Custom Manufacturing, APIs & Intermediates
Phone 49 7821 585 0
Market Pharmaceutical
Mail info-lahr@seqens.com
More information

Surface: 48 000 m²

 

Lab surface: 700 m²

 

Capabilities:

  • Total reactor capacity: 92 m³
  • Reaction vessels: 1 to 6 300 L; temperature  -80°C to +250 °C
  • Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
  • Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
  • Autoclaves (operational range up to 100 bar)
  • Kilo-Lab: 3 reactors: 25 / 100 / 250 L

Flagship technologies:

  • Hydrogenation
  • Reductive amination
  • Organometallic reactions
  • Protected AADs (Aminoacid derivatives)
  • Carbonylation & Hydroformylation
  • Pressure aminolysis, other reactions under pressure
  • Cryogenic chemistry
  • Enantiopure synthesis
  • Cyanation high volumes (NaCN) C-C coupling
  • Reductions
  • Halogenation

Last inspections:

  • FDA 2018
  • German Pharma Authority 2018

Certifications:

  • GMP
  • ISO 9001
  • ISO 50001

Number of scientists: 25

 
Address 19 Route de Meulan
78520 Limay
Business Line Contract Manufacturing & Proprietary APIs
Phone +33 1 34 78 87 87
Market Pharmaceutical
Mail info.cdmo@seqens.com
More information

Capabilities: 

  • 70 m³ of GMP reactors
  • 100 L – 8 000 L vessels

Flagship technologies: 

  • Optical resolution
  • Enzymatic hydrolysis
  • Enantioselective reduction
  • Low-temperature reactions (-80 °C)
  • Specific reduction
  • Hydrogenation (40 bar)
  • Organomagnesium compounds
  • Thin-layer distillation
Address Expansia, Route d'Avignon
30390 Aramon
Business Line Contract Manufacturing
Phone +33 4 66 57 01 01
Market Pharmaceutical
Mail info.cdmo@seqens.com
More information

Capabilities: 

  • 100 m³ of GMP reactors
  • 50 L – 10 000 L vessels

Flagship technologies: 

  • Organometallic chemistry
  • Large-scale hydrogenation
  • Diborane chemistry
  • Ethylene oxide reactions
  • Biocatalysis platform
  • Polymer production (PLGA)
  • Enzymatic synthesis Skraup reactions
Address 15 Avenue des Frères Lumière
38300 Bourgoin-Jallieu
Business Line Contract Manufacturing & Fine Chemicals
Phone +33 4 74 93 63 33
Market Pharmaceutical
Mail Acceuil.bourgoin@seqens.com
More information

Flagship technologies: Distillation

Address 35 Avenue Jean Jaurès
92390 Villeneuve-la-Garenne
Business Line Contract Manufacturing & Proprietary APIs
Phone +33 1 34 78 87 87
Market Pharmaceutical
Mail info.cdmo@seqens.com
More information

Capabilities: 

  • 70 m³ of GMP reactors
  • 100 L – 8 000 L vessels

Flagship technologies: 

  • Optical resolution
  • Enzymatic hydrolysis
  • Enantioselective reduction
  • Low-temperature reactions (-80 °C)
  • Specific reduction
  • Hydrogenation (40 bar)
  • Organomagnesium compounds
  • Thin-layer distillation
Address Messukentänkatu 8
20210 Turku
Business Line Contract Manufacturing & Proprietary APIs
Phone +358 2 330 5542
Market Pharmaceutical
Mail info@pcasfinland.fi
More information

Surface: 11 678 m²

Lab surface: 695 m²

Capabilities: 

  • 4 separate modules
  • 72 m³ reactor capacity-
  • 250 L – 6300 L vessels

Flagship technologies:

  • Biphosphonate chemistry
  • Hydrogenation (20 bar)
  • Chlorination
  • Cyanation (NaCN) in separate installations
  • Reduction with complex hydrids
  • Biocatalysis
  • Manufacturing of parenteral/injectable APIs
  • Separate production modules and final processing facilities
 

Last inspections:

  • FDA 2017
  • PMDA 2018
  • FIMEA 2018

Number of scientists: 16

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