Capabilities:

• Total reactor capacity: 92 m³
• Reaction vessels: 1 to 6 300 L; temperature  -80°C to +250 °C
• Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
• Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
• Autoclaves (operational range up to 100 bar)
• Kilo-Lab: 3 reactors: 25 / 100 / 250 L

Flagship technologies:

• Hydrogenation
• Reductive amination
• Organometallic reactions
• Protected AADs (Aminoacid derivatives)
• Carbonylation & Hydroformylation
• Pressure aminolysis, other reactions under pressure
• Cryogenic chemistry
• Enantiopure synthesis
• Cyanation high volumes (NaCN) C-C coupling
• Reductions
• Halogenation

Last inspections:

• FDA 2018
• German Pharma Authority 2018

Certifications:

• GMP
• ISO 9001
• ISO 50001

Capabilities: 

• 70 m³ of GMP reactors
• 100 L – 8 000 L vessels

Flagship technologies: 

• Optical resolution
• Enzymatic hydrolysis
• Enantioselective reduction
• Low-temperature reactions (-80 °C)
• Specific reduction
• Hydrogenation (40 bar)
• Organomagnesium compounds
• Thin-layer distillation

Capabilities: 

• 100 m³ of GMP reactors
• 50 L – 10 000 L vessels

Flagship technologies: 

• Organometallic chemistry
• Large-scale hydrogenation
• Diborane chemistry
• Ethylene oxide reactions
• Biocatalysis platform
• Polymer production (PLGA)
• Enzymatic synthesis Skraup reactions

Surface: 5, 600 m²

Lab surface: 460 m²

Capabilities:

• Process Research – Custom synthesis & synthetic route evlaution from g – kg for API’s or intermediates
• Process Development – Custom synthesis from kg – metric tons
• cGMP Small Molecule API Manufacturing (Phase 1, Phase 2, Phase 3, Commerical)
• cGMP Medical Grade Polymers, Analytical Method Development

Flagship technologies: 

• Controlled Substances
• Cryogenic Chemistry -90°C
• Lyophilization, Small/Large Scale Chromatography
• Tangential Flow Filtration

Last inspection: July 2018 FDA Inspection

Capabilities:

• 4 kilo-labs
• 2 cGMP pilot plants with 11 multipurpose reactors from 100 L to 2 800 L (total capacity of 12 m³)
• Temperature range: -15/+150°C  (hastelloy reactor: -80/+200°C)
• 3 finishing rooms (agitated filter dryers, filters, dryers, milling and sieving equipments)

Flagship technologies:

• Crystallization expertise and technologiesd(salt, co-crystal and polymorph screenings, process development)
• Process Safety expertise and tecnologies
• Flow chemistry for fine chemicals
• Potent API process development
• Genotoxic Impurities
• Issue Management
• Generic A.P.I Solid state expertis

Last inspection: ANSM  October 2018

Lab surface: 1 000 m²

Capabilities:

• Controlled substances (Schedule II-V)
• 5 Kilo-Labs