GMP Drug Delivery Manufacturing
Seqens’ R&D centers provide extensive expertise in tailor made-polymers design to meet your needs. Our portfolio of polymers, all manufactured under GMP standards, includes:
Expansorb®
- Expansorb® portfolio of PLA/PLGA copolymers used as functional excipients for controlled and slow drug release (weeks to months) with a single injection. We can provide small or bulk quantities for screening PLA/PLGA ± PEG polymers (up to 50 references available) to improve formulation during early-stage development.
Vitamin E TPGS
- Vitamin E TPGS (Vitamin E, D-alpha-tocopheryl polyethylene, glycol, 1000 succinate), a water-soluble derivative of natural Vitamin E, widely used as an excipient in drug delivery systems because it acts as a solubilizer and enhances permeability to improve bioavailability of poorly absorbed drugs.
Our locations
Lahr
Germany
Address
Raiffeisenstraße 4
77933 Lahr
77933 Lahr
Business Line
Custom Manufacturing, APIs & Intermediates
Phone
49 7821 585 0
Market
Pharmaceutical
Mail
info-lahr@seqens.com
More information
Surface: 48 000 m²
Lab surface: 700 m²
Capabilities:
- Total reactor capacity: 92 m³
- Reaction vessels: 1 to 6 300 L; temperature -80°C to +250 °C
- Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
- Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
- Autoclaves (operational range up to 100 bar)
- Kilo-Lab: 3 reactors: 25 / 100 / 250 L
Flagship technologies:
- Hydrogenation
- Reductive amination
- Organometallic reactions
- Protected AADs (Aminoacid derivatives)
- Carbonylation & Hydroformylation
- Pressure aminolysis, other reactions under pressure
- Cryogenic chemistry
- Enantiopure synthesis
- Cyanation high volumes (NaCN) C-C coupling
- Reductions
- Halogenation
Last inspections:
- FDA 2018
- German Pharma Authority 2018
Certifications:
- GMP
- ISO 9001
- ISO 50001
Number of scientists: 25
Limay
France
Address
19 Route de Meulan
78520 Limay
78520 Limay
Business Line
Contract Manufacturing & Proprietary APIs
Phone
+33 1 34 78 87 87
Market
Pharmaceutical
Mail
info.cdmo@seqens.com
More information
Capabilities:
- 70 m³ of GMP reactors
- 100 L – 8 000 L vessels
Flagship technologies:
- Optical resolution
- Enzymatic hydrolysis
- Enantioselective reduction
- Low-temperature reactions (-80 °C)
- Specific reduction
- Hydrogenation (40 bar)
- Organomagnesium compounds
- Thin-layer distillation
Aramon
France
Address
Expansia, Route d'Avignon
30390 Aramon
30390 Aramon
Business Line
Contract Manufacturing
Phone
+33 4 66 57 01 01
Market
Pharmaceutical
Mail
info.cdmo@seqens.com
More information
Capabilities:
- 100 m³ of GMP reactors
- 50 L – 10 000 L vessels
Flagship technologies:
- Organometallic chemistry
- Large-scale hydrogenation
- Diborane chemistry
- Ethylene oxide reactions
- Biocatalysis platform
- Polymer production (PLGA)
- Enzymatic synthesis Skraup reactions
Porcheville
France
Address
ZI de Limay 2, 8 Rue de Rouen
78440 Porcheville
78440 Porcheville
Phone
+33 1 34 79 57 00
Market
Pharmaceutical, Specialty Ingredients & Cosmetics
Mail
ContactSeqensPCV@seqens.com
More information
Surface: 40 000 m²
Lab surface: 2 000 m²
Capabilities:
- 4 kilo-labs
- 2 cGMP pilot plants with 11 multipurpose reactors from 100 L to 2 800 L (total capacity of 12 m³)
- Temperature range: -15/+150°C (hastelloy reactor: -80/+200°C)
- 3 finishing rooms (agitated filter dryers, filters, dryers, milling and sieving equipments)
Flagship technologies:
- Crystallization expertise and technologiesd(salt, co-crystal and polymorph screenings, process development)
- Process Safety expertise and tecnologies
- Flow chemistry for fine chemicals
- Potent API process development
- Genotoxic Impurities
- Issue Management
- Generic A.P.I Solid state expertis
Last inspection: ANSM October 2018
Certification: cGMP
Number of scientists: 110
Other: Ecosystem Pharma with integrated services
Devens
United States
Address
88 Jackson Road, Building 649
MA 01434 Devens
MA 01434 Devens
Business Line
R&D center
Phone
(978) 772 2111
Market
Pharmaceutical
Mail
Accueil@seqens.com
More information
Lab surface: 1 000 m²
Capabilities:
- Controlled substances (Schedule II-V)
- 5 Kilo-Labs
Number of scientists: 30
Newburyport
United States
Address
9 Opportunity Way
MA 01950 Newburyport
MA 01950 Newburyport
Business Line
Custom Early Phase Pharmaceutical
Phone
(978) 462 5555
Market
Pharmaceutical
Mail
Early Stage: derek.richards@seqens.com
Custom Manufacturing: don.laferle@seqens.com
Proprietary API: laurent.alexandre@seqens.com
Custom Manufacturing: don.laferle@seqens.com
Proprietary API: laurent.alexandre@seqens.com
More information
Surface: 5, 600 m²
Lab surface: 460 m²
Capabilities:
- Process Research – Custom synthesis & synthetic route evlaution from g – kg for API’s or intermediates
- Process Development – Custom synthesis from kg – metric tons
- cGMP Small Molecule API Manufacturing (Phase 1, Phase 2, Phase 3, Commerical)
- cGMP Medical Grade Polymers, Analytical Method Development
Flagship technologies:
- Controlled Substances
- Cryogenic Chemistry -90°C
- Lyophilization, Small/Large Scale Chromatography
- Tangential Flow Filtration
Last inspection: July 2018 FDA Inspection
