Pre-GMP API / Intermediates Catalog
SEQENS offers a full range of proprietary intermediates (non-regulated, RSM and GMP), from our pre-GMP and GMP plants. We supply pharma intermediates with a wide range of quantities.
Using in-house technologies such as Biocatalysis or Flow chemistry, Seqens can also develop non-exclusive key intermediates for the production of your APIs at customer’s request to support your derisking strategy or new development.
OUR PORTFOLIO INTERMEDIATES INCLUDES:
- D-Serine for production of N-BOC D-Serine or Cycloserine for example
- Acid chlorides derivatives like Decanoyl chloride, 5-Chlorovaleroyl chloride
- Acid & anhydrides like 3-phenyl propionic acid, Benzoic anhydride
- Amino derivatives (R)-2-(Aminomethyl)-1-ethylpyrrolidine
- Benzofuran derivatives like (2-Butylbenzofuran-3-yl)(4-hydroxyphenyl)methanone for Amiodarone
- Acrolein derivatives like 2-(2-bromoethyl) 1,3 dioxolane
- Phosphonates like : Tetraisopropyl methylene diphosphonate for Clodronate for example
- Quinuclidinone HCL and its derivatives R-(-)-3-Hydroxyquinuclidine…
- Tartaric acid derivatives for chemical resolutions
- Thiophene derivatives like 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene
Our locations
Couterne
France61410 Couterne
Surface: 120, 000 m²
Capabilities: 190 m³ of ISO 9001 reactors and kilo-lab
Flagship technologies: Most standard organic synthesis reactions (large volumes)
Certifications: ISO 9001
Lahr
Germany77933 Lahr
Surface: 48 000 m²
Lab surface: 700 m²
Capabilities:
- Total reactor capacity: 92 m³
- Reaction vessels: 1 to 6 300 L; temperature -80°C to +250 °C
- Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
- Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
- Autoclaves (operational range up to 100 bar)
- Kilo-Lab: 3 reactors: 25 / 100 / 250 L
Flagship technologies:
- Hydrogenation
- Reductive amination
- Organometallic reactions
- Protected AADs (Aminoacid derivatives)
- Carbonylation & Hydroformylation
- Pressure aminolysis, other reactions under pressure
- Cryogenic chemistry
- Enantiopure synthesis
- Cyanation high volumes (NaCN) C-C coupling
- Reductions
- Halogenation
Last inspections:
- FDA 2018
- German Pharma Authority 2018
Certifications:
- GMP
- ISO 9001
- ISO 50001
Number of scientists: 25
Bourgoin-Jallieu
France38300 Bourgoin-Jallieu
Flagship technologies: Distillation
