With 6 cGMP/ FDA inspected plants in Europe and the United States for commercial production supported by two pre-GMP (ISO 9001) sites in France, our customers have access to a powerful industrial network of facilities with a high level of quality, safety and environmental compliance.

Seqens invests on an ongoing basis in its production sites to provide the pharmaceutical industry with state-of-the-art equipment combined with cutting-edge technology in organic chemistry associated with proprietary gene shuffling technology for unique biocatalytic routes.

We conduct GMP manufacturing of APIs or intermediates from kilo to multi-ton quantities. Our range of scale and seamless collaboration within our manufacturing sites allow Seqens to accommodate most projects regardless of size and complexity.

Our services include

  • Process and analytical validation
  • Kilo-scale, pilot scale and commercial multi-ton cGMP manufacturing
  • Production in two locations for supply chain security
  • Quality control and quality assurance
  • Back integration of early intermediates for  supply chain security, cost or quality control
  • Special technologies like cryogenic, hydrogenation, biocatalysis
    HPAPI containment down to 100 ng/m3 OEL ( kilo scale to 200 kg batch size )
  • Process optimization and second generation process for cost control
    Regulatory support and filings Process and analytical validation
  • Kilo-scale, pilot scale and commercial multi-tons cGMP manufacturing
  • Production in two locations for supply chain security
  • Quality control and quality assurance
  • Back integration of early intermediates for  supply chain security, cost or quality control
  • Special technologies like cryogenic, hydrogenation, biocatalysis
  • HPAPI containement down to 100 ng/m3 OEL ( kilo scale to 200 kg batch size )
  • Process optimisation and second generation process for cost control
  • Regulatory support and filings

Production sites

Address Expansia, Route d'Avignon
30390 Aramon
Business Line Contract Manufacturing
Phone +33 4 66 57 01 01
Market Pharmaceutical
Mail info.cdmo@seqens.com
More information

Capabilities: 

  • 100 m³ of GMP reactors
  • 50 L – 10 000 L vessels

Flagship technologies: 

  • Organometallic chemistry
  • Large-scale hydrogenation
  • Diborane chemistry
  • Ethylene oxide reactions
  • Biocatalysis platform
  • Polymer production (PLGA)
  • Enzymatic synthesis Skraup reactions
Address 15 Avenue des Frères Lumière
38300 Bourgoin-Jallieu
Business Line Contract Manufacturing & Fine Chemicals
Phone +33 4 74 93 63 33
Market Pharmaceutical
Mail Acceuil.bourgoin@seqens.com
More information

Flagship technologies: Distillation

Address Route de Lassay
61410 Couterne
Business Line Lubbricant Additives, Fine Chemicals
Phone +33 2 33 37 50 20
Market Specialty Ingredients
Mail info.AS@seqens.com
More information

Surface: 120, 000 m²

Capabilities: 190 m³ of ISO 9001 reactors and kilo-lab

Flagship technologies: Most standard organic synthesis reactions (large volumes)

Certifications: ISO 9001

Address 9 Opportunity Way
MA 01950 Newburyport
Business Line Custom Early Phase Pharmaceutical
Phone (978) 462 5555
Market Pharmaceutical
Mail derek.richards@seqens.com
More information

Surface: 5, 600 m²

Lab surface: 460 m²

Capabilities:

  • Process Research – Custom synthesis & synthetic route evlaution from g – kg for API’s or intermediates
  • Process Development – Custom synthesis from kg – metric tons
  • cGMP Small Molecule API Manufacturing (Phase 1, Phase 2, Phase 3, Commerical)
  • cGMP Medical Grade Polymers, Analytical Method Development

Flagship technologies: 

  • Controlled Substances
  • Cryogenic Chemistry -90°C
  • Lyophilization, Small/Large Scale Chromatography
  • Tangential Flow Filtration

Last inspection: July 2018 FDA Inspection

Address Messukentänkatu 8
20210 Turku
Business Line Contract Manufacturing & Proprietary APIs
Phone +358 2 330 5542
Market Pharmaceutical
Mail info@pcasfinland.fi
More information

Surface: 11 678 m²

Lab surface: 695 m²

Capabilities: 

  • 4 separate modules
  • 72 m³ reactor capacity-
  • 250 L – 6300 L vessels

Flagship technologies:

  • Biphosphonate chemistry
  • Hydrogenation (20 bar)
  • Chlorination
  • Cyanation (NaCN) in separate installations
  • Reduction with complex hydrids
  • Biocatalysis
  • Manufacturing of parenteral/injectable APIs
  • Separate production modules and final processing facilities
 

Last inspections:

  • FDA 2017
  • PMDA 2018
  • FIMEA 2018

Number of scientists: 16

Address 35 Avenue Jean Jaurès
92390 Villeneuve-la-Garenne
Business Line Contract Manufacturing & Proprietary APIs
Phone +33 1 34 78 87 87
Market Pharmaceutical
Mail info.cdmo@seqens.com
More information

Capabilities: 

  • 70 m³ of GMP reactors
  • 100 L – 8 000 L vessels

Flagship technologies: 

  • Optical resolution
  • Enzymatic hydrolysis
  • Enantioselective reduction
  • Low-temperature reactions (-80 °C)
  • Specific reduction
  • Hydrogenation (40 bar)
  • Organomagnesium compounds
  • Thin-layer distillation
Address 88 Jackson Road, Building 649
MA 01434 Devens
Business Line R&D center
Phone (978) 772 2111
Market Pharmaceutical
Mail Accueil@seqens.com
More information

Lab surface: 1 000 m²

Capabilities:

  • Controlled substances (Schedule II-V)
  • 5 Kilo-Labs

Number of scientists: 30

 
Address ZI de Limay 2, 8 Rue de Rouen
78440 Porcheville
Phone +33 1 34 79 57 00
Market Pharmaceutical, Specialty Ingredients & Cosmetics
Mail ContactSeqensPCV@seqens.com
More information

Surface: 40 000 m²

 

Lab surface: 2 000 m²

 

Capabilities:

  • 4 kilo-labs
  • 2 cGMP pilot plants with 11 multipurpose reactors from 100 L to 2 800 L (total capacity of 12 m³)
  • Temperature range: -15/+150°C  (hastelloy reactor: -80/+200°C)
  • 3 finishing rooms (agitated filter dryers, filters, dryers, milling and sieving equipments)

Flagship technologies:

  • Crystallization expertise and technologiesd(salt, co-crystal and polymorph screenings, process development)
  • Process Safety expertise and tecnologies
  • Flow chemistry for fine chemicals
  • Potent API process development
  • Genotoxic Impurities
  • Issue Management
  • Generic A.P.I Solid state expertis

Last inspection: ANSM  October 2018

Certification: cGMP

 

Number of scientists: 110

 

Other: Ecosystem Pharma with integrated services

 
Address 70 Allée Graham Bell
30000 Nîmes
Phone +33 4 66 70 64 64
Market Pharmaceutical, Specialty Ingredients & Cosmetics
Mail seqensrdnimesinfo@seqens.com
More information

Surface: 1 000 m²

Lab surface: 500 m²

Capacities:

  • 1 kilo-lab in fermentation (80 L total capacity)
  • Robotic platform for highthroughput screening (HTS)
  • Analytical platform for chromatography (GC, GC-MS, U-HPLC)

Flagship technologies: 

  • Protein engineering
  • Microbiology aerobic & anaerobic
  • Syngas fermentation
  • Enzymes & strains fermentation
  • Biochemistry
  • Biocatalysis
  • Design of experiments (DoE)
  • Data mining

Number of scientists: 19