Surface: 11 678 m²

Lab surface: 695 m²

Capabilities: 

• 4 separate modules
• 72 m³ reactor capacity-
• 250 L – 6300 L vessels

Last inspections:

• FDA 2019
• PMDA 2018
• FIMEA 2018

Number of scientists: 16

Seqens group headquarter

Surface: 120, 000 m²

Capabilities: 190 m³ of ISO 9001 reactors and kilo-lab

Flagship technologies: Most standard organic synthesis reactions (large volumes)

Certifications: ISO 9001

Capabilities: 

• 70 m³ of GMP reactors
• 100 L – 8 000 L vessels

Flagship technologies: 

• Optical resolution
• Enzymatic hydrolysis
• Enantioselective reduction
• Low-temperature reactions (-80 °C)
• Specific reduction
• Hydrogenation (40 bar)
• Organomagnesium compounds
• Thin-layer distillation

EcoVadis CSR Rating: Gold Certification 2019

Last inspections :

• FDA 2018
• ANSM 2019

Capabilities: 

• 100 m³ of GMP reactors
• 50 L – 10 000 L vessels

Flagship technologies: 

• Organometallic chemistry
• Large-scale hydrogenation
• Diborane chemistry
• Ethylene oxide reactions
• Biocatalysis platform
• Polymer production (PLGA)
• Enzymatic synthesis Skraup reactions

Last inspections:

• FDA 2018
• ANSM 2021

EcoVadis CSR Rating: Silver certification

Capabilities: 

• 70 m³ of GMP reactors
• 100 L – 8 000 L vessels

Flagship technologies: 

• Optical resolution
• Enzymatic hydrolysis
• Enantioselective reduction
• Low-temperature reactions (-80 °C)
• Specific reduction
• Hydrogenation (40 bar)
• Organomagnesium compounds
• Thin-layer distillation

Last inspections:

• ANSM 2019
• ANVISA (Brasil) 2018
• FDA 2016

Capabilities:

• 4 kilo-labs
• 2 cGMP pilot plants with 11 multipurpose reactors from 100 L to 2 800 L (total capacity of 12 m³)
• Temperature range: -15/+150°C  (hastelloy reactor: -80/+200°C)
• 3 finishing rooms (agitated filter dryers, filters, dryers, milling and sieving equipments)

Flagship technologies:

• Crystallization expertise and technologiesd(salt, co-crystal and polymorph screenings, process development)
• Process Safety expertise and tecnologies
• Flow chemistry for fine chemicals
• Potent API process development
• Genotoxic Impurities
• Issue Management
• Generic A.P.I Solid state expertis

Last inspection: ANSM  October 2018

Surface: 1 000 m²

Lab surface: 500 m²

Capacities:

• 1 kilo-lab in fermentation (80 L total capacity)
• Robotic platform for highthroughput screening (HTS)
• Analytical platform for chromatography (GC, GC-MS, U-HPLC)

Flagship technologies: 

• Protein engineering
• Microbiology aerobic & anaerobic
• Syngas fermentation
• Enzymes & strains fermentation
• Biochemistry
• Biocatalysis
• Design of experiments (DoE)
• Data mining

Capabilities:

• Total reactor capacity: 92 m³
• Reaction vessels: 1 to 6 300 L; temperature  -80°C to +250 °C
• Multi-purpose state of the art cGMP facilty: 4 independent, vertical integrated production trains 800 L train, 2 x 3 000 L trains plus 1 x 3 000 L low temperature hydrogenation reactor and 6 000 L train
• Classic two-floor layout Facility: 20 vessels with capacity between 800 and 6 000 L (glaslined and SS)
• Autoclaves (operational range up to 100 bar)
• Kilo-Lab: 3 reactors: 25 / 100 / 250 L

Flagship technologies:

• Hydrogenation
• Reductive amination
• Organometallic reactions
• Protected AADs (Aminoacid derivatives)
• Carbonylation & Hydroformylation
• Pressure aminolysis, other reactions under pressure
• Cryogenic chemistry
• Enantiopure synthesis
• Cyanation high volumes (NaCN) C-C coupling
• Reductions
• Halogenation

Last inspections:

• FDA 2018
• German Pharma Authority 2018

Certifications:

• GMP
• ISO 9001
• ISO 50001

Surface: 2,264m²

Certifications:

• ISO 9001-2015
• GMP

Flagship Technologies:

• Cryogenic reactions (-70 °C to -85 °C)
  Thermal rearrangements/thermal cyclizations
• Reductions / Brominations / nitrations/ sulphonations
• Cyclic amidations
• Dihydroxylations
• Chiral chemistry
• Optical resolutions

Capabilities:

• Total multi-purpose reactor volume 35 Reactors
• Total multi-purpose reactor volume 53,010 L
• Range of reactor volumes 50-4000 L (Stainless Steel, Glass-Lined, High Vacuum distillations, Hydrogenation 20 bar)

Number of Scientists: 5

Lab surface: 500 sqm

Flagship technologies:

• Complex chemistry
• Enzymatic Process Development
• Solid State (Polymorphism Research / Salts / Co-Crystals)

Number of Scientists: 33

Lab surface: 3000 sqm

Capabilities:

• Number of Reactors 54
• Total multi-purpose reactor volume 110,000 L
• Wide range of reactor volumes 10-12,000 L (Stainless Steel, Hastelloy, Glass-Lined, Hydrogenation 50 bar)

Flagship Technologies:

• Enzymatic Process Development
• Solid State (Polymorphism Research / Salts / Co-Crystals)
• Particle Design
• Spray Drying & Bioavailability Enhancing

Highly Potent containment capabilities including micronization up to OEL<1µg/m3

Last inspections:

• Israeli Ministry Of Health in January 2019
• US FDA in July 2018

Number of Scientists: 42

Surface: 5, 600 m²

Lab surface: 460 m²

Capabilities:

• Process Research – Custom synthesis & synthetic route evlaution from g – kg for API’s or intermediates
• Process Development – Custom synthesis from kg – metric tons
• cGMP Small Molecule API Manufacturing (Phase 1, Phase 2, Phase 3, Commerical)
• cGMP Medical Grade Polymers, Analytical Method Development

Flagship technologies: 

• Controlled Substances
• Cryogenic Chemistry -90°C
• Lyophilization, Small/Large Scale Chromatography
• Tangential Flow Filtration

Last inspection: July 2018 FDA Inspection

Lab surface: 1 000 m²

Capabilities:

• Controlled substances (Schedule II-V)
• 5 Kilo-Labs

Surface: 5, 600 m²

Lab surface: 460 m²

Capabilities:

• Process Research – Custom synthesis & synthetic route evlaution from g – kg for API’s or intermediates
• Process Development – Custom synthesis from kg – metric tons
• cGMP Small Molecule API Manufacturing (Phase 1, Phase 2, Phase 3, Commerical)
• cGMP Medical Grade Polymers, Analytical Method Development

Flagship technologies: 

• Controlled Substances
• Cryogenic Chemistry -90°C
• Lyophilization, Small/Large Scale Chromatography
• Tangential Flow Filtration

Last inspection: July 2018 FDA Inspection